Is D81 a billable code?
No. D81 is a header code that groups 17 more specific codes. Use one of the billable codes listed on this page instead.
ICD-10-CM FY2027 diagnosis code
D81: Combined immunodeficiencies
Header code: not billableValid for dates of service October 1, 2026 to September 30, 2027
D81 groups related diagnoses under combined immunodeficiencies. It cannot be used on a claim by itself. Choose the billable code below that matches the patient's record.
Billable codes under D81
- D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesis
- D81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
- D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
- D81.30Adenosine deaminase deficiency, unspecified
- D81.31Severe combined immunodeficiency due to adenosine deaminase deficiency
- D81.32Adenosine deaminase 2 deficiency
- D81.39Other adenosine deaminase deficiency
- D81.4Nezelof's syndrome
- D81.5Purine nucleoside phosphorylase [PNP] deficiency
- D81.6Major histocompatibility complex class I deficiency
- D81.7Major histocompatibility complex class II deficiency
- D81.810Biotinidase deficiency
- D81.818Other biotin-dependent carboxylase deficiency
- D81.819Biotin-dependent carboxylase deficiency, unspecified
- D81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
- D81.89Other combined immunodeficiencies
- D81.9Combined immunodeficiency, unspecified
D81 questions
What does D81 mean?
D81 is the ICD-10-CM code for Combined immunodeficiencies. It is in chapter 3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).
Code titles come from the official ICD-10-CM files published by the CDC National Center for Health Statistics. Always check payer rules and the clinical record before billing.