Is Z16 a billable code?
No. Z16 is a header code that groups 19 more specific codes. Use one of the billable codes listed on this page instead.
ICD-10-CM FY2027 diagnosis code
Z16: Resistance to antimicrobial drugs
Header code: not billableValid for dates of service October 1, 2026 to September 30, 2027
Z16 groups related diagnoses under resistance to antimicrobial drugs. It cannot be used on a claim by itself. Choose the billable code below that matches the patient's record.
Billable codes under Z16
- Z16.10Resistance to unspecified beta lactam antibiotics
- Z16.11Resistance to penicillins
- Z16.12Extended spectrum beta lactamase (ESBL) resistance
- Z16.13Resistance to carbapenem
- Z16.19Resistance to other specified beta lactam antibiotics
- Z16.20Resistance to unspecified antibiotic
- Z16.21Resistance to vancomycin
- Z16.22Resistance to vancomycin related antibiotics
- Z16.23Resistance to quinolones and fluoroquinolones
- Z16.24Resistance to multiple antibiotics
- Z16.29Resistance to other single specified antibiotic
- Z16.30Resistance to unspecified antimicrobial drugs
- Z16.31Resistance to antiparasitic drug(s)
- Z16.32Resistance to antifungal drug(s)
- Z16.33Resistance to antiviral drug(s)
- Z16.341Resistance to single antimycobacterial drug
- Z16.342Resistance to multiple antimycobacterial drugs
- Z16.35Resistance to multiple antimicrobial drugs
- Z16.39Resistance to other specified antimicrobial drug
Z16 questions
What does Z16 mean?
Z16 is the ICD-10-CM code for Resistance to antimicrobial drugs. It is in chapter 22, Factors influencing health status and contact with health services (Z00-Z99).
Code titles come from the official ICD-10-CM files published by the CDC National Center for Health Statistics. Always check payer rules and the clinical record before billing.